

In the process, we have shortened the printed version of the book by 40 pages. In this Third Edition, we have updated the entire book to reflect new molecular insights. Third, we complete the presentation of important physiological principles by pairing them with illustrations from pathophysiology, thereby putting physiology in a clinical context. Second, we still integrate physiological concepts from the level of DNA and epigenetics to the human body, and everything in between. After more than two decades, we have become so accustomed to each other’s writing styles that we can literally finish each other’s sentences. Even so, we continued to edit jointly and in real time- monitor to monitor-using desktop-sharing software.

By the time we began editing the Third Edition, one of us had moved from New Haven to Cleveland. In the First Edition, we achieved this singleness of pen by sitting-shoulder to shoulder-at a computer as we rewrote the primary copy of our authors, line by line. First, we combine the expertise of several authors with the consistency of a single pen. The 3-fold philosophy that has guided us in the previous editions has endured as we prepared the Third Edition. We are delighted that the physiological community so eagerly welcomed the Second Edition of our book.
